Master Ascorbate - Resources

Vitamin C for Optimal Health
Vitamin C is an essential nutrient that is involved in many biochemical reactions and processes. Unfortunately, many factors can negatively affect vitamin C metabolism. Aging, diet, drugs, and lifestyle factors, such as smoking or exercise, can all influence individual vitamin C requirements. A vast amount of scientific literature supports the use of higher doses of vitamin C—doses that are difficult to obtain from diet alone—for promoting optimal health.

A Critical Antioxidant
Vitamin C is the major plasma antioxidant and is believed to be the most versatile water-soluble antioxidant. Vitamin C can readily quench a variety of reactive free radicals, thereby protecting tissues throughout the body.

Enzyme Cofactor
Vitamin C plays critical roles in numerous biochemical processes due to its role as a cofactor for multiple enzymes. For instance, it is involved in the biosynthesis of collagen and carnitine and the metabolism of tyrosine, neurotransmitters, drugs, and steroids.

Collagen and Connective Tissue Support
Vitamin C is required for the synthesis of collagen, which is a primary component of connective tissue, including skin. Specifically, vitamin C is involved in the hydroxylation of praline to form hydroxyproline—a process not only important in maintaining the integrity of connective tissue, but also vital for superficial tissue regeneration. Research confirms that ascorbic acid acts as a specific inducer of the collagen pathway.

  1. Anderson R, Oosthuizen R, Martiz R, et al. The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr 1980;33:71-76.
  2. Combs GF. The Vitamins: Fundamental Aspects in Nutrition and Health. 2nd ed. New York: Academic Press; 1998.
  3. Heuser G, Vojdani A. Enhancement of natural killer cell activity and T and B cell function by buffered vitamin C in patients exposed to toxic chemicals: the role of protein kinase-C. Immunopharmacol Immunotoxicol 1997;19(3):291-312.
  4. Shils ME, Olson JA, Shike M, eds. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Lippincott,Williams & Wilkins; 1999.
  5. Vojdani A, Gheneum M. In vivo effect of ascorbic acid on enhancement of human natural killer cell activity.Nutr Res 1993;13:753-64.
  6. Vojdani A, Namatalla G. Enhancement of human natural killer cytotoxic activity by vitamin C in pure and augmented formulations. J Nutr Env Med 1997;7:187-95.



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